Enzyme Function

[KhanTran3K]

Hi I am not sure if this has been answered before but near the end of lecture from Monday, Dr. Lavelle mentioned a few examples of transition metals and their biological significance. One of these was Mn, Ni, Cu, and Zn and their impact on enzyme function. How do these transition metals play a role in enzyme function? Does it have to do with shape? Thanks

[HilaGelfer_2H]

Hi,

Transition metals are located in the active site of the enzyme and help the molecules bond to the enzyme.

I hope this helps :)

[Aaina 2D]

Hi! These particular transition metals interact and bind with amino acids or other solutions in the active site of an enzyme. Hope this helps :)

[Sydney Jensen 3L]

The molecules bond to the transition metals that are location in the active site of the enzyme.

[MMorcus2E]

Hey! I agree with what was said above. These elements are found in the active sites. When an enzyme gets added, it interacts with these atoms and plays a role in changing the shape of the active site to allow for better binding of the ligands.

[Becca Nelson 3F]

Hello! these transitions metals can help in the active site. The active site is essential to the enzyme as this is where the substrate binds.

[Joey_Okumura_1E]

Transition metals are located in the active site of enzymes and help the enzymes bond to their substrate. Substrates fit into an active site of an enzyme like a lock and key. Enzymes are very specific and only bond to a specific enzyme to catalyze a specific reaction. Therefore, it is very important that the correct transition metals are located in the active site so the enzyme can function properly. Additionally, Enzymes lower the activation energy of a reaction by reorienting the bonds in the substrate so they can more easily form the products. I believe that the transition metals may form chelates to disrupt these bonds.

[Marc Lubman 3B]

Also, a particular reason why transition metals are so useful in enzyme formation is that they can have a variety of oxidation states and form many bonds, which allows for the formation of very complex molecules. Enzymes, due to their very specific functions, are extremely complex molecules, and so the use of a transition metal that can form a specific number of bonds in a particular arrangement helps create an enzyme with a very particular function.

[Ariel Guan 1H]

transition metals are located in the active sites of enzymes, and they help substrates/molecules bind to the enzyme.

[Neha Jonnalagadda 2D]

These transition metals are important because they play a role in the active site of a lot of proteins in the cells in organisms. They are essential to many cellular processes to occur.