Cisplatin

[Jessica Berejikian]

Dr. Lavelle mentioned Cisplatin a lot-- what is the significance of this chemotherapy drug in relation to what we are currently learning?

[Nathan Sigel 2k]

Cisplatin is an example of a coordination compound that, when introduced into a cell, has the ability to stop cell replication due to specific interactions that prevent DNA helicase from successfully splicing open the DNA. It is important to know the keyword in cis-platinum, which is cis. This means that the NH3 groups and Cl groups are clustered on the same side. When introduced to certain base pairs in DNA (I believe guanine and some other one), the chlorine atoms fall off of the coordination compound, and instead, 2 coordinate covalent bonds are formed between adjacent nitrogen in DNA bases. This action of 2 adjacent covalent bonds proves to be too difficult for DNA helicase to break, unlike in translation, where there only exists 1 coordinate covalent bond between the coordination compound and DNA bases. I think the important thing to know here is how the adjacent coordinate covalent bonds work, and why the cis geometry as supposed to the trans geometry causes this.

[Jessica Servoss 1H]

Hi Jessica!
Cisplatin was used as an example for how ligands and coordination compounds can have biological significance. At the heart of Cisplatin, there is a platinum ion, which has two chlorine ions on its "cis" side, and two ammonia molecules on the other. These chlorine ions bind to DNA and form coordination compounds within the strands. Due to this molecule being in the middle of the DNA strand, replication cannot occur properly, and thus stops cell division of a rapidly dividing cell (cancer).
Hope this helps! :)

[305824279]

Cisplatin was used as an example of a coordinate compound whose structure would affect its ability to perform its function. The prefix (cis-) tells us that both chlorines are on the same side of the compound as opposed to being on opposite sides which would make it transplatin (which does not function as well as cisplatin because of the position of the chlorines).

[Bobak Pourrahimi 2L]

Cisplatin is important because it is an example that ties in a real life application of both coordinate compounds and the structure of molecules. Specifically, cis-platin has its attached chlorines on the same side, which allow it to bind to the DNA of malignant cells and stop replication. A similar, yet slightly different molecule, transplatin, has the chlorines on opposite sides, which do not allow it to function properly in binding with the DNA strands.

[Aryan Gajjar 3D]

Cisplatin is an anticancer drug that is used to treat a variety of malignancies. Cisplatin is a chemotherapy drug that is used to treat a variety of cancers. It's a platinum-containing chemotherapeutic medication. It is used to delay or stop the development of cancer cells.

[Katherine Li 1A]

Like everyone else says, cisplatin is important in chemotherapy because it can bind to DNA and prevent DNA replication, preventing a cell from dividing. You should also note that this is only possible with cisplatin, rather than transplatin, because cisplatin can form two coordinate bonds on the same side of the molecule, which is necessary to completely prevent new nucleotides from attaching to the DNA and growing a new strand.

[Samantha Melin 2E]

Cisplatin has the ability to bind to DNA because the both of the chlorines in the compound are located on the same side (hence the name cis), allowing it to bind in two places on a strand of DNA, preventing it from replicating. Note, that the fact that cisplatin can bind in two places makes it bidentate. Cisplatin is often used a chemotherapy drug because it can stop the replication of cancerous cells. Transplatin is similar to cisplatin, but the chlorines in the compound are on either side of it, so it cannot bond to the same molecule in two places.

[Mia Orr 3B]

Cisplatin is a well known chemotherapy drug that is useful because having both Cl atoms on the same side of the molecule allows it to form a coordination compound with DNA and inhibit cell division.

[Aida Fraser 2I]

what are the ligands in cisplatin? NH3 groups and Cl groups?

[azurexrose]

Yes, the ligands in cisplatin are chlorine and NH3

[Heba Bounar 3K]

Hi!

Cisplatin is used for chemotherapy because it stops cell division by forming a coordination complex with DNA and bonding to two adjacent G base pairs. Cisplatin is able to do this because the two Cl groups are on the same side.

Hope this helps!

[Omar Alkhalili 1J]

Hello! Cisplatin is used as a chemotherapy drug to stop cell division. The significance of the structure is that the chlorine groups are on the same side. In the trans-isomer, the chlorine groups are on opposite sides so the effect is different.

[Palig Kechichian 3F]

They're important in terms of structure. Cis-platin (Cl on the same side) is able to stop cell reproduction (the aim is to stop reproduction of cancerous cells in treatment) because of its structure- The Cl's bind to DNA and stop cell division. Trans-platin (Cl on opposite sides) is unable to do this, and therefore cannot be used for such treatment.

[Rainy Liu Ruoshui_2K]

Cisplatin is important because it has a square-planar shape and has its Cl on the same side. Thus it is bidentate.