Heterocyclic amines

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Kate Zeile 2D
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Joined: Sat Jul 22, 2017 3:01 am

Heterocyclic amines

Postby Kate Zeile 2D » Fri Mar 16, 2018 7:25 am

I was watching a nutrition/health video the other day that mentioned the carcinogenic effects of heterocyclic amines, and I want to know more. How are heterocyclic amines produced and why are they carcinogenic?

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Joined: Fri Sep 29, 2017 7:03 am

Re: Heterocyclic amines

Postby Jessica_Singh_1J » Fri Mar 16, 2018 11:00 am

Basically, heterocyclic amines are produced when protein-rich meats like beef, fish, and poultry are cooked at high temperatures (basically well-done meat). They're carcinogenic in that they produce DNA adducts (segments of DNA bound to a cancer-causing chemical) through the formation of N-C bonds at guanine bases. HCAs can cause mutations, deletions, and insertions at the DNA level and are thus highly mutagenic.

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