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Cisplatin has the two chlorine atoms on the same side of the molecule (vs on opposite sides). When it binds to the guanine base on the DNA molecule, a chlorine is released from cisplatin and binds to a lone pair on the guanine. Since there are two chlorines next to each other, the cisplatin can bind to two guanines next to each other and create a bond strong enough to block DNA replication. In the trans conformation, the bond isn't strong enough to prevent DNA replication. That's what I got from Lavelle's lecture, hope it helps!
cisplatin has two chlorine atoms next to each other, so it can bind to two guanines at a time. the nitrogen in the guanine displaces the chlorines in cisplatin, so cisplatin can bind to the guanine. this stops dna replication
cisplatin works in chemotherapy as it has two Cl- atoms on one side and 2 NH3 molecules on the other side. This causes the bent shape and for cisplatin to be bidentate while transplatin would have one Cl and one NH3 on each side causing it be monodentate. The transplatin would have a harder time staying connected to DNA when the DNA polymerase attempts to replicate the DNA.
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