Cisplatin binding

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Jessica Li 4F
Posts: 115
Joined: Fri Aug 09, 2019 12:16 am

Cisplatin binding

Postby Jessica Li 4F » Fri Nov 22, 2019 1:39 pm

Can someone explain how cisplatin binds to DNA again? I understand that it binds to an exposed N atom on guanine, but do the Cl atoms then get displaced for Pt to bind to nitrogen? Also, would the bonds be intramolecular or intermolecular? Thanks!

Kylie Lim 4G
Posts: 110
Joined: Sat Aug 17, 2019 12:15 am

Re: Cisplatin binding

Postby Kylie Lim 4G » Fri Nov 22, 2019 3:51 pm

Guanine in the n7 position has an exposed nitrogen. The Cl in cisplatin will displace the nitrogen, and bond to the guanine.

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