Cisplatin

[kpang_4H]

Why cisplatin is used for chemotherapy and not transplatin?

[saigorijavolu2k]

Cisplatin attacks the dna of the cancer cells and inhibits their repair. Transplatin cannot do that.

[JohannaPerezH2F]

I got this online and hope it answers your question. "Cisplatin molecules are known to be attacked by water molecules before they react with DNA. ... 3) When cis-form of (NH3)2 Pt 2+ reacts with two Guanines in DNA, the two N atoms in Guanines can readily bind to the Pt atom in cisplatin. The transplatin due to steric reasons does not provide that opportunity."

[Karyn How 1J]

I think it's due to the fact that cisplatin is polar and transplatin is nonpolar. The polarity probably impacts the cancer cells and is more effective in chemotherapy.

[Ananta3G]

While I don't think we need to know this aspect of the chemo drug because Lavelle did not really mention it, I think it's because the energy cost associated with using cisplatin is a lot lower than using transplatin. Also, I think the structure of cisplatin makes it able to actually bind to the Gs and stop DNA replication while translplatin cannot.

[Areena H 2K]

I think its due to the fact that cisplatin can bind 2 regions of the DNA and block cell replication. Even though it has side effects such as killing normal cells, it does effectively kill the cancer cells.

[Chantel_2I]

I believe it is because cisplatin has the chlorines pointing in the same general direction, so cisplatin can bond more strongly to DNA, whereas transplatin can only bind to the DNA on one site at a time and can easily be removed off of the DNA strand.

[Quynh Vo]

cisplatin is more efficient to bonding to cells because of its structure

[Doreen Liu 4D]

Its structure helps it to bind to DNA molecules and prevent replication.