Cisplatin

Moderators: Chem_Mod, Chem_Admin

Angelo Mapalo 4E
Posts: 50
Joined: Sat Aug 24, 2019 12:18 am

Cisplatin

Postby Angelo Mapalo 4E » Sat Dec 07, 2019 11:08 pm

Why can the cis- version of the complex form 2 bonds and why can the trans- version of the complex only form 1 bond?

505306205
Posts: 97
Joined: Thu Jul 25, 2019 12:15 am
Been upvoted: 1 time

Re: Cisplatin

Postby 505306205 » Sat Dec 07, 2019 11:13 pm

Cis can form two bonds because the Chlorines are on the same side, while in trans they are opposite of each other.

Martina
Posts: 111
Joined: Thu Jul 25, 2019 12:16 am

Re: Cisplatin

Postby Martina » Sun Dec 08, 2019 12:22 am

The chlorines are on the same side and bind to DNA twice, which stops cell division.

Kyle Thorin
Posts: 50
Joined: Sat Aug 24, 2019 12:16 am

Re: Cisplatin

Postby Kyle Thorin » Sun Dec 08, 2019 1:11 am

In the cis- molecule, the Chlorines are on the same side so they are both able to bind to adjacent Guanines on a DNA strip. in transplatin the Cl will be on opposite side, so only one Cl will be able to bond with the Guanine.

selatran1h
Posts: 52
Joined: Fri Aug 30, 2019 12:16 am

Re: Cisplatin

Postby selatran1h » Sun Dec 08, 2019 1:17 am

In the cis- molecule, the chlorines occur on the same side. In the trans- molecule, chlorine occurs on the opposite side

Anna Heckler 2C
Posts: 102
Joined: Wed Sep 18, 2019 12:18 am

Re: Cisplatin

Postby Anna Heckler 2C » Sun Dec 08, 2019 1:54 am

In the cis-molecule, the chlorines are on the same side. They bond to adjacent guanines by kicking off a nitrogen on a DNA molecule. The trans-platin version of the molecule has Cl's oriented on opposite sides, so when one of the Cl's binds to a guanine, the DNA Polymerase can easily kick off the Cl and continue DNA replication.


Return to “Biological Examples”

Who is online

Users browsing this forum: No registered users and 0 guests