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H2O is typically used as a solvent in its liquid form, so the concentration does not change much before and after the reaction occurs. Since it mostly stays the same, it would not have an affect on the rate of the reaction.
We don't include H2O (l) in our calculations of Ka and Kb because water is going to be present in so much excess in both the reactants and the products that if we plugged it into the equation the two numbers would just cancel each other out.
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