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Pseudo rate laws are generated because rate laws cannot be used for reactions with more than one reactant since changes in both reactants, most of the times, occur simultaneously. With Pseudo rate laws, the concentration of one reactant must be in large excess ( so the concentration is essentially constant and unchanging). So to answer your question, as long as the concentration is large enough so that the change is not significant to change the concentration itself, then it would be considered as "very large".
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