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Jedrick Zablan 3L
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Joined: Sat Aug 17, 2019 12:17 am


Postby Jedrick Zablan 3L » Sun Nov 24, 2019 2:47 am

Why is cisplatin able to be used as an anticancer treatment, but transplatin isn't? How does their structures change their functions?

Sarah Zhari 1D
Posts: 103
Joined: Sat Sep 14, 2019 12:16 am

Re: Transplatin?

Postby Sarah Zhari 1D » Sun Nov 24, 2019 10:28 am

Cisplatin can form coordination compounds with DNA by binding to the lone pair of electrons on nitrogen in the DNA base guanine, whereas transplatin is unable to do so.

Aayush Patel 3B
Posts: 51
Joined: Thu Jul 25, 2019 12:17 am

Re: Transplatin?

Postby Aayush Patel 3B » Sun Nov 24, 2019 1:10 pm

In addition, by forming a coordination complex with DNA, cisplatin is able to stop further cell division.

Posts: 102
Joined: Thu Jul 11, 2019 12:15 am

Re: Transplatin?

Postby 305385703 » Sun Nov 24, 2019 1:24 pm

transplatin IS able to form coordination complex with DNA, but only one. The middle bond on the cisplatin and transplatin molecule prevents rotation in the molecule so transplatin can only form a coordination complex on one side, but the other side is facing the other way and can't rotate to form a second coordination complex. transplatin, on the other hand, has two places (NH3) where it can form coordination compounds, and thus it's bond with DNA is stronger. since it can stay on the DNA, it prevents it from unraveling and thus allowing the cell to duplicate.

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